Why are vaccines against many human viral diseases still unavailable; an historic perspective?
نویسندگان
چکیده
منابع مشابه
Recombinant viruses as vaccines against viral diseases.
Vaccine approaches to infectious diseases are widely applied and appreciated. Amongst them, vectors based on recombinant viruses have shown great promise and play an important role in the development of new vaccines. Many viruses have been investigated for their ability to express proteins from foreign pathogens and induce specific immunological responses against these antigens in vivo. General...
متن کاملWhy many polymers are so fragile: A new perspective.
Many polymers exhibit much steeper temperature dependence of their structural relaxation time (higher fragility) than liquids of small molecules, and the mechanism of this unusually high fragility in polymers remains a puzzle. To reveal additional hints for understanding the underlying mechanism, we analyzed correlation of many properties of polymers to their fragility on example of model polym...
متن کاملDNA vaccines for viral diseases.
DNA plasmids encoding foreign proteins may be used as immunogens by direct intramuscular injection alone, or with various adjuvants and excipients, or by delivery of DNA-coated gold particles to the epidermis through biolistic immunization. Antibody, helper T lymphocyte, and cytotoxic T lymphocyte (CTL) responses have been induced in laboratory and domesticated animals by these methods. In a nu...
متن کاملEmerging viral diseases: an Australian perspective.
Update International Editors update Dr. Mackenzie is professor and head of the Department of Microbiology and Parasi-tology, University of Queensland, Brisbane, Aus-tralia. His research interests include the epidemiology, ecology, and molecular biology of mosquito-borne and emerging zoonotic viruses. With a few exceptions, emerging diseases in Australia are similar to those in other industriali...
متن کاملWhy is There Still no Human Vaccine Against Lyme Borreliosis?
Lyme disease, transmitted by ticks, is a complex illness that can be difficult to diagnose but easy to treat in most early cases, yet difficult in its latest stage. Every year, infections with Borrelia burgdorferi sensu lato spirochetes cause thousands of new cases of illness around the world, including people with a normal immunological reaction. Prevention in the form of vaccines is difficult...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Medical Virology
سال: 2019
ISSN: 0146-6615,1096-9071
DOI: 10.1002/jmv.25593